Hereditary Neuropathy with Liability to Pressure Palsies HNPP Explained Causes, Symptoms and
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🧠 Nerve Palsies – Quick Nursing Revision Understand the classic hand deformities seen in peripheral nerve injuries: 🔹 Wrist Drop → Radial nerve palsy 🔹 Preacher’s Hand → Median nerve palsy 🔹 Ulnar Claw → Ulnar nerve palsy 🔹 Combined Claw → Median Ulnar nerve palsy 📌 Also note sensory loss and muscle atrophy patterns — very important for clinical assessment, viva, and MCQs. 📚 Save this post for AIIMS NORCET, NCLEX, NEET-PG & Nursing exams. ⚠️ For educational purposes only. #NervePalsy #Nur
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HNPP is a hereditary demyelinating neuropathy. Most cases come from a 1.5 Mb deletion on chromosome 17p11.2 that removes one copy of PMP22. PMP22 is a Schwann cell protein that helps compact and stabilize peripheral myelin. With only half the normal amount, myelin becomes fragile and forms tomacula (sausage-like thickenings) with disorganized paranodes and shorter internodes. Potassium leak lowers conduction safety, so nerves block under pressures most people tolerate. That biology explains the
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HNPP is a hereditary demyelinating neuropathy. Most cases come fro…
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