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0:59
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MedLecturesMadeEasy
Mechanism of action of opioids
Opioid agonists produce analgesia by binding to G protein-coupled receptors (GPCRs) in the brain and spinal cord regions involved in the transmission and modulation of pain Opioid drugs mimic endogenous compounds: endorphins, enkephalins, and dynorphins that bind to opioid receptors. Four opioid receptor types: mu (μ), kappa (κ), delta (δ ...
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More than 800,000 Americans have died from opioids since 1999. But there’s another drug-related crisis in the US: the exploitative, underregulated drug rehab industry. Many of the roughly 50 million Americans who battle substance abuse rely on this underregulated for-profit industry that too often exploits patients, fails to properly treat them, or even worse. Journalist Shoshana Walter has been reporting on the rehab industry for almost a decade. Walter, a staff writer at the Marshall Project,
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