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CD40 is a stimulatory agent, not a checkpoint inhibitor. Rather than releasing the brakes on an existing immune response, it helps recruit and activate multiple immune cell types at the tumor site. That is a critical distinction because checkpoint inhibitors are limited when the immune system is not already engaged.The reason intratumoral delivery matters here is that CD40 receptors are expressed across many healthy tissue types. Systemic delivery has consistently run into off-target toxicity. P
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