Former President Joe Biden’s diagnosis of an aggressive, stage-4 prostate cancer has reignited a long-simmering medical debate: When should men get screened for prostate cancer? For decades, doctors have wrestled with how often to screen men for the disease and when to start and stop.

Joe Biden’s metastatic prostate cancer diagnosis, coupled with revelations about his decline in recent years, has renewed chatter and anxiety about the former president’s health.

His death, after a public battle with esophageal cancer, prompted an outpouring of grief from colleagues.