Kickoff is set for 1 p.m. ET on Sunday at Caesars Superdome. The Buccaneers are favored by 3.5 points in the latest Saints vs. Buccaneers odds, while the over/under is 42.5 points via SportsLine consensus. Before entering any Buccaneers vs. Saints picks, you'll want to see the NFL predictions from the advanced computer model at SportsLine.

The Tampa Bay Buccaneers are on the road this week to take on the New Orleans Saints hoping to erase last week’s loss to the Falcons with a win this week and move to 4-2. Tampa Bay will see the return of several key players including right tackle Luke Goedeke as well as safety Antoine Winfield,

The Lions return to the scene of last December’s disputed 20-19 loss, which was decided by a disallowed 2-point conversion. Though the Cowboys got out of Pittsburgh with a win, Jared Goff’s offense is better equipped to exploit the absences of DeMarcus Lawrence and likely Micah Parsons than the Steelers were.