The publication, titled “ Comparative characterization of Cas12f orthologs reveals mechanistic features underlying enhanced genome editing efficiency” highlights the potential of MG119-28 (formally ...

A compact Cas12f nuclease shows high editing efficiency in human cells, with structural insights enabling an engineered variant potentially suited for future AAV‑compatible delivery.

Mammoth Biosciences researchers have developed NanoCas, an ultracompact CRISPR nuclease, demonstrating its ability to perform gene editing in non-liver tissues, including skeletal muscle, using a ...

The discovery of CRISPR-Cas gene editing technology has revolutionized biological research, providing new insights and opportunities for the advancement of several industries. However, the ...

A single protein bolted to the inner membrane of a bacterial cell can shred a virus’s DNA before that genetic material ever reaches the interior. That is the central finding behind SNIPE, a newly ...

New research shows that the nuclease domain of the E. coli RecBCD helicase plays a key role in regulating DNA binding and the extent of base pair melting during double-strand break repair. Deleting ...

A new tool could reduce costs for diagnosing infectious diseases. Biomedical researchers from The University of Texas at Austin have developed a new, less expensive way to detect nuclease digestion – ...

GMP Salt Active GENIUS ™ Nuclease is developed using ACROBiosystems' unique enzyme AI evolution platform, based on wild-type Serratia marcescens endonuclease. It maintains high specific activity, ...

NIH-funded UT team and colleagues from Metagenomi Thereapeutics discovered highly efficient enzyme could enable targeted gene editing within the human body.