The United States men's national team kicked off the international break on a strong note with a dominant victory over Panama but things will look a little different when they head to Guadalajara to face Mexico Tuesday night.

Christian Pulisic, Weston McKennie will miss USMNT's game against Mexico on Tuesday as new coach Mauricio Pochettino tries to manage their workload.

The departures of Pulisic and McKinnie, as well as Marlon Fossey, Zack Steffen and Ricardo Pepi, further deplete the team’s player pool ahead of Tuesday’s friendly.

The U.S. Soccer Federation said the players will not be in action in order to return to their clubs in Europe.