The Titans had a Week 5 bye, allowing Levis (shoulder) and defensive lineman Jeffery Simmons (elbow) to heal. Levis was a full participant Wednesday, while Simmons was limited. Tennessee's last 2 games have gone over (2 under, 2 over overall); Indianapolis' last 2 games have gone over (3 over, 2 under overall).

The Tennessee Titans had an early bye in Week 5. For the Colts, this means they will be facing an opponent who will have the rest advantage as well as additional time to prepare for this matchup. Prior to the bye, the Titans secured their first win of the season to improve to 1-3 on the year.