The model is also backing Iowa (+6.5) to cover the spread on the road against USC, while the Over (52.5) hits 58% of the time in TCU vs. BYU. Before locking in your Week 12 college football picks, be sure to check out the top college football betting picks from SportsLine's advanced computer model.

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The No. 21 Iowa Hawkeyes, led by quarterback Mark Gronowski, face the No. 17 USC Trojans, led by quarterback Jayden Maiava on Saturday, Nov. 15, 2025 at Los Angeles Memorial Coliseum in Los Angeles, Calif.

The No. 17 ranked USC Trojans face the No. 21 Iowa Hawkeyes hoping to avoid an upset at home in this intriguing Big Ten showdown between Top ranked 25 foes.

On Saturday, the USC football team will host Iowa at the Coliseum. With both teams ranked in the top 25, it is a massive game in the Big Ten and College Football Playoff races. What can we expect when the Trojans face off with the Hawkeyes?

What channel is Iowa football vs. USC on today? Here's how to watch, with start time, TV schedule, live streaming and game odds.

Tied with Oklahoma at No. 10 in last week's rankings, Texas moved back eight spots to No. 18 after falling at Georgia, 35-10. The Longhorns trailed 14-10 after the third quarter before the Bulldogs ran away in the final frame with two touchdown passes and a touchdown rush from quarterback Gunner Stockton.

No. 17 USC kept its College Football Playoff hopes alive with a 26-21 comeback win over No. 21 Iowa at the rain-soaked Coliseum Saturday afternoon.