"Despite significant advances in computational protein design in recent years, designing protein binders from scratch remains challenging," explains the study's first author, Kateryna Maksymenko. "To ...

We set out to develop general methods for designing proteins that bind peptides in helical conformations. To fully leverage recent advances in protein design, we explored both parametric and deep ...

Since its release in 2024, the open-source platform BindCraft, developed at EPFL, has already disrupted the world of protein design. Physical interactions between proteins influence anything from cell ...

There has been considerable recent progress in de novo protein binder design 1,2,3,4,5,6. Both energy based 1 and deep learning methods, such as RFdiffusion 2, now enable design of protein binders ...

Physical interactions between proteins influence anything from cell signaling and growth to immune responses, so the ability to control these interactions is of great interest to biologists.