Eukaryotic translation elongation factors orchestrate the delivery of aminoacyl-tRNAs to the ribosomal A-site during protein synthesis, yet their roles extend far beyond housekeeping. Among these, the ...
Life depends on the precise functioning of several proteins synthesized in cells by ribosomes. This diverse set of proteins, known as a proteome, is maintained by the robust translation elongation of ...
Growth, proliferation and survival of cancer cells rely upon the continuous presence of unstable cancer driver proteins such as c-Myc, Cyclin D1 and MCL-1. Consequently, protein synthesis inhibitors ...
Nuclear-encoded regulatory proteins control mitochondrial translation. A few, however, are encoded by the mitochondrial DNA (mtDNA) and are produced by the mitochondrial translation machinery.
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