Comparison of Menopausal Symptoms During the First Year of Adjuvant Therapy With Either Exemestane or Tamoxifen in Early Breast Cancer: Report of a Tamoxifen Exemestane Adjuvant Multicenter Trial ...

CARBONIC anhydrase is a zinc metalloenzyme that reversibly catalyzes the hydration of carbon dioxide to bicarbonate and hydrogen ions according to the following equation 1: Blood was obtained from ...

THE characteristic features of an ideal diuretic can easily be enumerated. In practice, however, a compound possessing all these desirable properties has yet to be found. Because of the multitudinous ...

Carbonic anhydrase inhibitors (CAIs) have long represented a versatile class of agents in clinical medicine. By targeting the zinc metalloenzymes responsible for rapidly converting carbon dioxide to ...

In a recent study published in Nature Chemical Biology, University of Cambridge scientists used zebrafish models of tauopathies — a group of neurodegenerative diseases driven by tau protein ...

Researchers have discovered a new group of carbonic anhydrase enzymes that do not require any metal ions for their activity, which improves our knowledge of the global carbon cycle and may be ...

Patients with advanced chronic kidney disease who treat glaucoma with topical carbonic anhydrase inhibitors may have a higher risk of long-term dialysis and metabolic acidosis. Kidney disease patients ...

Mesothelioma is an aggressive tumor with a poor prognosis. Histological diagnosis of mesothelioma using limited tissue samples can be challenging. Carbonic anhydrase IX (CAIX) is a transmembrane ...