Sepsis, a critical condition characterized by life-threatening organ dysfunction, arises from a dysregulated host response to infection. The resultant immunosuppression constitutes the primary ...

Researchers found that CD4+ T cells can be classified into 18 categories and 12 distinct gene programs, and that characteristic changes in CD4+ T cell profiles are associated with autoimmune disease, ...

This study, led by Dr. Panpan Jiang and collaborators at Tongji Medical College, explores the critical role of the Dedicator of Cytokinesis 8 (DOCK8) gene in the differentiation of helper T cells, ...

For decades, cancer immunotherapy has focused primarily on CD8 + cytotoxic T lymphocytes as the main executors of tumor cell killing. However, growing clinical and single-cell sequencing evidence ...

Researchers have engineered a synthetic Notch receptor system to directly label and profile cells interacting with developing T cells in the thymus. The study identified a broad network of immune and ...

CD4+ T-cells, primarily considered to play a supportive role in the anti-tumor immune response, have been seen to actively kill cancer cells in a mouse model of melanoma. A recent study by a team at ...

Introduction Postpartum disengagement from HIV care increases risks for adverse maternal health outcomes and transmission of ...