Researchers have discovered a new mechanism for potassium channel inhibitor entry, which could improve the specificity of drugs targeting the channel. Upon binding to calcium ions, BK channels allow ...

BK and CaV1.3 channels interact early during biogenesis, assembling intracellularly before membrane localization, indicating coordinated processes for functional coupling.

Ion channels are attractive drug targets due to their importance in health and disease, but finding ways to target a specific ion channel selectively is a major challenge. Now, researchers have ...

Large-conductance calcium-activated potassium (BK) channels are critical determinants of smooth muscle function by mediating rapid feedback between intracellular calcium levels and membrane potential.

A new study has unveiled a precise picture of how an ion channel found in most mammalian cells regulates its own function ...

A new study has unveiled a precise picture of how an ion channel found in most mammalian cells regulates its own function with a “ball-and-chain” channel-plugging mechanism, according to investigators ...

A new study has unveiled a precise picture of how an ion channel found in most mammalian cells regulates its own function with a 'ball-and-chain' channel-plugging mechanism. The findings boost the ...