BK channels (large-conductance, Ca2+-dependent K+ channels) are essential for the regulation of important biological processes such as smooth muscle tone and neuronal excitability. New research shows ...

Researchers have discovered a new mechanism for potassium channel inhibitor entry, which could improve the specificity of drugs targeting the channel. Upon binding to calcium ions, BK channels allow ...

Ion channels are attractive drug targets due to their importance in health and disease, but finding ways to target a specific ion channel selectively is a major challenge. Now, researchers have ...

A new study has unveiled a precise picture of how an ion channel found in most mammalian cells regulates its own function with a “ball-and-chain” channel-plugging mechanism, according to investigators ...