Tipoff is set for 7:30 p.m. ET from Madison Square Garden in New York City. The Knicks are favored by 7.5 points in the latest Pistons vs. Knicks odds, according to the SportsLine consensus. The over/under is 223 points. Before entering any Knicks vs. Pistons picks, you'll want to see the NBA predictions from the model at SportsLine.

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Led by Brunson and Karl-Anthony Towns, the New York Knicks are among the top Over teams in the NBA (22-17-1) and sit seventh in points per game (116.6) and third in offensive rating (119.9). The Knicks are poised to expose a Detroit Pistons defense with clear cracks.

The Knicks hit the halfway mark at a low point of this roller-coaster season. Behind clutch 3-pointers from Malik Beasley and dominant offense from Cade Cunningham, the Pistons escaped Monday night with another victory at MSG,

The New York Knicks are struggling right now, as the team has lost 5 of their last 10 games. Knicks players aren’t happy with this losing skid, and are working to turn the ship back in the right direction.

Knicks center Karl-Anthony Towns has a bone chip in his right thumb to go along with the sprain he suffered in Monday's loss, sources confirmed.

The word became official about 90 minutes before game time, but was predictable nearly 48 hours earlier that Karl-Anthony Towns would be out of action Wednesday night as the Knicks took on the Philadelphia 76ers at the Wells Fargo Center.