San Francisco generally recovers from early season slumps. Geno Smith generally loses to the Niners — he’s 0-3 against them all-time with a passer rating more than 10 points lower against his divisional rival than his Seattle average. The Bears’ defense is absolutely legit and this rookie QB they’ve got might not be too bad, either!

Now, in Week 6, it's up to those teams that lost to find their footing as we approach midseason. Week 6 kicks off with a Thursday night showdown between the San Francisco 49ers and Seattle Seahawks.

The Arizona Cardinals (2-3) are 5-point underdogs heading into their matchup on Sunday, October 13, 2024 against the Green Bay Packers (3-2).NFL odds courtesy of BetMGM Sportsbook. Odds updated