Do NFL experts have faith in the Panthers under the bright lights? Here are their picks for Monday night's matchup with the 49ers . . .

If the Panthers want to come out victorious in their first prime-time showcase since 2023, they'll have to go through an old friend to do it.

The San Francisco 49ers can gain plenty of financial flexibility by releasing wide receiver Brandon Aiyuk once the 2025 season comes to a close.

Preview the Week 12 matchup between the San Francisco 49ers and Carolina Panthers with predictions, odds, over/under, spread, betting lines and more.

Throughout the 2025 NFL season, the San Francisco 49ers have traveled to all corners of the United States. From divisional battles across California, they’ve headed east to New York, down to Florida to face the Tampa Bay Buccaneers, and into Texas for a matchup with DeMeco Ryans’ Houston Texans.

El receptor lesionado de los 49ers de San Francisco Brandon Aiyuk vio anulados aproximadamente 27 millones de dólares en dinero prácticamente garantizado en su contrato para el próximo año, en lo que

Georgia opted for a run-heavy approach in its final tuneup before a showdown against Georgia Tech, and the Charlotte 49ers couldn’t keep up.

Pineiro has a grade 1 hamstring strain and is considered “week-to-week.” The 49ers signed Matt Gay to the practice squad earlier this week, and he will kick against the Panthers on Monday night. Bethune has a high-ankle sprain and is expected to miss multiple weeks but will not go on injured reserve with the team’s off week in Week 14.